By erasing Skull Face, XOF, and those parasites, they'd well cause chaos for Gensokyo...
Ps Yoshika as a female skull?
well Cipher was a case of why having too many isolated cells is a bad idea, since you have a shared pool of resources without centralized control or oversight.
I was thinking moreso MGS2-era patriots, since they are all about the control of information.
Of anyone to be a female skull, I'd think yoshika would work. Koishi would make a good zero considering
both go into total isolation and lose their cognition