This is probably a parody of something.

Looks like an Akira parody but my memory's fuzzy so I'll let someone confirm first

Yup. It's a parody of Akira.

Definitely. The bike is unforgettable.

I imagine her screaming that out in a very loud but deadpan voice.

That's not Nagato Yuki, is it?

It's Nagato (check original filename) in Mikuru's waitress outfit on Kaneda's bike.

piespy said:
It's Nagato (check original filename) in Mikuru's waitress outfit on Kaneda's bike.

who ever did it got her character wrong as far as I can tell. I don't think she would doing anything like that in the picture lol.

GWAR said:
That's not Nagato Yuki, is it?

That IS Nagato Yuki.

Yuki: ASAKURAAAAAAAAAAAAAA!!!
Ryoko: That's "Miss" Asakura to you, Nagato!